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Ask Doctor Frank!'As a service provider to the Medical Profession, we feel it is useful to have a topical web page where busy doctors would have the opportunity to catch up with information and views covering subjects which affect their world.

We would welcome additional contributions from active doctors as well as from other sources.

September 2008

Dr Frank Says......

Concern over Tofu
Researchers from The University of Loughborough studied 719 elderly Indonesians in the region of Java. They report in the Journal of Dementia and Geriatric Cognitive Disorders that Tofu, a soy product, when consumed at least once a day was associated with memory loss, especially in the over 68s. Tofu is rich in phytoestrogens which promotes damage to cells by free radicals. However they also suggest that the brain damage may be caused by formaldehyde, which is used in Indonesia as a tofu preservative.

Men have a biological clock too
It has long been known that women have age "window" in which they are more like to conceive. A paper from France presented at the conference of The European Society of Human Reproduction, held in Barcelona, followed 12,200 French couples having fertility treatment and their results showed that the chance of a successful pregnancy falls if the man is over 35. The study was based on treatment at the Eylau Centre in Paris over the time span January 2002 and December 2006. Preliminary findings were that DNA damage in sperm was the main factor in reduced chance of pregnancy.

Malaria in the UK
A report from The Health And Protection Agency, published in The BMJ, identified 6753 cases of malaria in the UK in the five years from 2002 to 2006, which is a 30% increase over the last 15 years. Since 1987 there have been 39000 case of malaria and 25000 of these were caused by plasmodium falciparum which is the most likely to cause a fatality and of the 25000 183 died. Only 40% of UK citizens traveling to infected areas take prophylaxis the report says!

Poor fertility made worse by drinking coffee
Too much coffee can reduce the chance of pregnancy in a woman who drinks coffee say researchers from Raboud University in Nijmegan in the Netherlands. They used lifestyle questionnaires in women who received IVF treatment between 1985 and 1995. They found that drinking alcohol 3 or more times a week carried the same risk as 4 cups of coffee a day. They also estimated that a 36 year old woman who smoked, drank 4 cups of coffee a day, alcohol 3 times a week and was overweight, and went through 3 cycles of IVF would only have a 5% chance of pregnancy. On the other hand, a woman of healthy weight, who did not smoke, drink alcohol or coffee would have a 15% chance of pregnancy.

A new type of CJD identified in the US
Ten people have so far died from a fatal, fast advancing form of dementia called PSPr, scientists report from the US National Disease Pathology Center in Ohio. The patients exhibit additional symptoms to those encountered with CJD such as the inability to speak and move. Post mortem examination of brain tissue shows the familiar sponginess together with tiny holes. The UK National CJD Surveillance Centre in Edinburgh is in contact with Ohio watching for any cases in the UK.

Blood pressure and dementia

A study from Imperial College, published in Lancet Neurology, found that hypotensive drugs reduce the risk of developing dementia by 13%. They say that only 50% of those over 65 years receive ideal hypotensive control and 25% of those over 65 probably have undiagnosed hypertension.

New evidence on cot death syndrome
The European Molecular Biology Laboratory in Italy, report in Science that low levels of serotonin in infant mice trigger rapid changes in heart rate and temperature leading to sudden death. This is similar to findings published in the US in 2006. The researchers are now looking at factors which may cause the serotonin imbalance.

And potential new treatment of Malaria

Scientists in Melbourne have identified eight proteins on the parasite that enable it to stick to the surface of a hi-jacked cell. They say that removing just one of these proteins renders the parasite unable to infect. Professor Walter Cowman of The Walter and Eliza Hall Institute in Melbourne says that targeting these proteins would be a key to fighting the disease.

Vaccines against superbugs?

Sir Liam Donaldson, Chief Medical Officer, says that vaccination against MRSA and C. diff. could help reduce the risk to patients. He says that vaccines should be available within 10 years. Between 2005 and 2008 there were more than 8000 hospital deaths attributable to these two pathogens.

And finally…………..
A 92 year old grey haired man comes into the consulting room and sits down in front of the doctor. "What can I do for you sir?," says our doctor friend. "Well," says the 92 year old, "I'm having sex regularly with most of the 18-25 year old girls in my neighbourhood and they're all very satisfied." "Oh," says the doctor, "What's the problem?" "There's no problem," said the man, "I just want to tell everyone about it!"

Please let us let us have your constructive observations on this page and any views covering other subjects. E-mail, website@locumlink.uk.com or drfrank@locumlink.uk.com . These can be published under a pseudonym for further comment.

Ed

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